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Prioritizing R&D Decisions

ANALYSIS OF DEVELOPMENT PROGRAMS FOR A NEW COMPOUND
THE CHALLENGE   ADDRESSING THE CHALLENGE

The client was developing a compound in a
new therapeutic area and wanted to ensure that the clinical program provided the claim structure required for market success.

In addition, the client needed a detailed understanding of how competitors had
implemented clinical development programs historically. The client also wanted to talk with
key opinion leaders (KOLs) to determine what enhancements should be considered in the
future.

Specifically, the client wanted to know if one development strategy resulted in faster
development and approval timelines relative to others.

 

MattsonJack's Science and Technology Assessment and Marketing Research practice specialties were combined to provide a clinical review of currently marketed products, including critical development issues, timelines and information for future programs.

CLIENT FEEDBACK

The client was pleased with MattsonJack's insight into key differences and similarities in development decisions regarding competitors' products and used this information in the development of its own compound.

The client forwarded MattsonJack's final report to its research and development team as a reference for future product development.

STRATEGY FOR AN EMERGING BIOPHARMA COMPANY: IDENTIFY AND EVALUATE COMMERCIALIZATION OPTIONS
     
THE CHALLENGE   ADDRESSING THE CHALLENGE

The client had a novel compound in Phase III development. As an emerging company with a limited commercial organization, it needed to determine the optimal commercialization strategy for this compound.

The client asked MattsonJack for assistance with the following:

  • outlining the time and resources required to create a viable and competitive commercial infrastructure that would enable the client to enter the U.S. market successfully
  • researching and analyzing commercialization options employed by other emerging biopharmaceutical firms
  • identifying, analyzing and evaluating the strengths and weaknesses of potential strategic commercialization alternatives, taking into account significant events that might occur before the anticipated product launch date

MattsonJack consultants used a multistep process that included:

  • analysis of the current and future competitive landscape and trends in the current market, including a detailed analysis of competitive products
  • evaluation of the product to determine how it most likely would compare to current and future competitors
  • identification, research, profiling and analysis of commercialization strategies employed by other emerging biopharmaceutical companies — insights obtained were employed to develop recommended commercial organization for the client
  • creation of a cost of commercialization model, including a proposed organizational structure for sales, marketing and support personnel
  • promotional response analysis to refine the required optimal resources
  • strategy scenario analysis, including scenario generation, analysis and rating of commercialization alternatives using a validated decision-analysis process
CLIENT FEEDBACK

The client's senior management was extremely pleased with both the process and the output — specifically complimenting the comprehensiveness of the analysis, commercial and market expertise and continuous involvement of senior consulting staff.

The CEO placed a high value on MattsonJack's willingness to "push back" and challenge the client's thinking.

The client has engaged MattsonJack on additional strategic projects.

PRIORITIZING R&D DECISION-MAKING
     
THE CHALLENGE   ADDRESSING THE CHALLENGE

The client was a research-based multinational corporation with a substantial investment in cardiovascular drugs. Recent R&D productivity, however, had been poor, and the client wanted to reassess its discovery and development programs from first principles.

The client engaged MattsonJack to develop a decision-enhancing database in all areas of cardiovascular disease that covered both technical and commercial considerations.

MattsonJack developed an initial review of all cardiovascular areas; the client selected 14 diseases for detailed study.

The client and MattsonJack agreed on the criteria to be used, and MattsonJack developed a comprehensive database for each of the diseases.

Information on epidemiology, market characteristics, products in development and unmet needs was collected in a consistent manner. MattsonJack developed a quantitative approach to criteria assessment and comparison across all diseases.

The final product was an easy-to-use database of tables, charts and descriptive analyses that enabled the client to focus its research and development expenditures.

CLIENT FEEDBACK

The client adopted the approach and database as its means of communication within research and development groups and between R&D and other company functions.

 
ANALYSIS OF MARKET OPPORTUNITIES
     
THE CHALLENGE   ADDRESSING THE CHALLENGE

The client was part of a team responsible for identifying and prioritizing commercially attractive market needs.

The client also needed to understand how multitier co-pays, pharmaceutical spending accounts and other factors influenced patients' product choices within and across diseases.

In addition to the traditional view of identifying clinical unmet needs, the client wanted to understand unmet treatment needs from a patient's perspective.

The client engaged MattsonJack to better understand the market and to combine the patient's view with the clinical assessment for a broader perspective of needs. Comprehending the patient's perspective would provide a more complete analysis of unmet needs for the identification of future development opportunities.

 

MattsonJack conducted qualitative interviews with patients in each area to formulate patient-centric language and issues.

Samples were recruited to reflect the epidemiology of each disease by race, age and gender. Internet surveys were conducted with patients in 21 disease areas, covering the following topics:

  • quality-of-life evaluation
  • medications taken, both prescription and non-prescription
  • ancillary non-medication, health-related programs
  • treatment goals and ability to achieve goals
  • satisfaction / frustration with treatments in general and other healthcare factors
  • payment methods for prescription pharmaceuticals

To help define the opportunity, patients' unmet needs were assessed across diseases based on the extent of health and emotional unmet need in relation to the size of the population of each disease.

Results then were compared to physicians' perspectives (in a different, concurrent project) to assess opportunities that were not identified previously.

The final deliverable included normative comparisons, using scales from clinical research approaches to assess health and quality of life.

CLIENT FEEDBACK

The client reported a high level of satisfaction, having successfully added a new perspective to its traditional approach that focused only on the physician's view.

 
 
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